Beyond the Claim: The Case for Direct-to-Responder RWE in U.S. Healthcare

In this Point of View, Matthew Heffler, MPH and William Rogers, PhD expose the structural limitations of relying solely on claims-based Real-World Evidence (RWE).

The fragmented multi-payer insurance system, cost-driven patient dropout, and the significant over-the-counter (OTC) market create systematic gaps – leaving populations most affected by access barriers underrepresented in your research.

The implications extend beyond the U.S. market: for global healthcare teams, understanding these gaps is critical when interpreting U.S. data, designing multinational studies, and building evidence strategies that rely on U.S. RWE as a key input.

Read the paper to uncover the limitations of relying solely on claims data for RWE in the U.S. and how capturing patient data directly through Direct-to-Responder RWE acts as a corrective measure – helping global and local teams achieve a more complete, inclusive view of the patient journey.