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A woman is posed to drop a soluble tablet into a glass of water

Beyond the Claim: The Case for Direct-to-Responder RWE in U.S. Healthcare

The U.S. healthcare claims system is a reputable source of secondary real-world data, but what happens when the patient falls out of the system?

In this Point of View, Matthew Heffler, MPH and William Rogers, PhD expose the structural limitations of relying solely on claims-based Real-World Evidence (RWE).

The fragmented multi-payer insurance system, cost-driven patient dropout, and the significant over-the-counter (OTC) market create systematic gaps – leaving populations most affected by access barriers underrepresented in your research.

The implications extend beyond the U.S. market: for global healthcare teams, understanding these gaps is critical when interpreting U.S. data, designing multinational studies, and building evidence strategies that rely on U.S. RWE as a key input.

Read the paper to uncover the limitations of relying solely on claims data for RWE in the U.S. and how capturing patient data directly through Direct-to-Responder RWE acts as a corrective measure – helping global and local teams achieve a more complete, inclusive view of the patient journey.  

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